TARGETING DNA METHYLATION ON TRANSGENERATIONAL CONSEQUENCES OF PRENATAL STRESS-INDUCED DEPRESSION

Background: Depression is a common mental disorder with disabilities and mortalities burden. Maternal stress during pregnancy has strong correlation the depression of children event in their adulthood phase. Abundant maternal cortisol transfer to fetus generates blunted hypothalamus-pituitary-adrenal axis response. Objective: To understand mechanism targeting DNA methylation on transgenerational consequences prenatal stress-induced depression. Methods: This review provides comprehensive explanation changes as well occasion new potential therapy that focused inhibitors from 33 trusted sources. Results: Higher fetal circulation led epigenetic development an antenatal situation. crucial genes such brain-derived neurotrophic factor (BDNF) nuclear receptor subfamily 3 group C member 1 (NR3C1) are responsible for molecular progression into next generation through transcriptional inhibition. Conclusion: Demethylation becoming target reduce risk who mother. The role plant bioactive compound demethylation agent promising need further exploration. Keywords: depression, methylation, stress.